Inhalte/ Contents

In the X-Student Research Group Digital Twins in Action: Optimizing Direct Oral Anticoagulant Use, students will develop a physiologically based pharmacokinetic (PBPK) model of the anticoagulant apixaban. This model functions as a “digital twin” of the human body, allowing simulations of absorption, distribution, metabolism, excretion, and the drug’s anticoagulant effect. The project explores how individual factors such as age, sex, or impaired liver and kidney function influence therapy outcomes. The course combines lectures, tutorials, and practical teamwork on literature research, data curation, and computational modeling. It is aimed at students from STEM fields, medicine, and computer science. Basic programming skills in Python are useful but can be acquired at the start of the course.

Kontakt/ Contact

koenigmx@hu-berlin.de

Link zum Vorlesungsverzeichnis/ Link to the course catalogue

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