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Are applicants required to draft a letter of intent (LOI) or a similar document as part of their proposal?

Yes, a letter of intent providing details of the topic for the envisages research proposal as well as a tentative list of participating PIs should be submitted to the coordinators of the Grand Challenge Initiative via grand-challenges@berlin-university-alliance.de by 15 March, 2020. An informal e-mail is sufficient for this purpose.